The primary objective of this study was to evaluate the effects of LM25 and LM50 on postprandial glucose excursions, and the secondary objective was to compare the effects of the two premixed insulin analogues and PHI70/30 on postprandial glucose excursions, glycosylated hemoglobin, body weight, and hypoglycemia. The gene discussed is INS; the disease is Hypoglycemia.