ACVR1 and congenital bilateral aplasia of vas deferens from CFTR mutation: However, inhibition of BMP signaling by genetic inactivation of BMPR1A prevents CAVD in a susceptible mouse model (Klotho−/−), and tissue-specific deletion of the Acvr1/ALK2 receptor leads to bicuspid aortic valve in mice and enhance pro-osteogenic changes during adulthood [132].