In all carcinoma samples, at least two immune tolerance mechanisms were detected simultaneously: By cooperation of DC, MDSC, Treg, and/or M2 macrophages, provide the cytokine stimuli for neoangiogenesis [25] and an inflamed microenvironment; Treg seem to keep NK cells out of the tumor and deactivate CD8+ cytotoxic T cells [25, 32]. The gene discussed is CD8A; the disease is neoplasm.