LIFR and breast cancer: At the same time, it is becoming increasingly clear that trans-endothelial migration and invasion of breast cancer cells in the vasculature is inhibited by metastasis suppressors, including TP63, LIFR, lysyl oxidase-like 4 (LOXL4), FOXF2, SSBP1, RAB1B, and TIEG1 (25, 40–47), suggesting that the migratory and invasive potential of breast cancer cells is ultimately determined by the balance in the activity of these molecules.