EPCAM and cancer: The cytotoxicity of this conjugate was tested in EpCAM-overexpressing cancer cell lines obtaining IC50 values from 2.5 × 10−10 to 2.0 × 10−12 M. Promising results were also observed in mice bearing BxPc-3 pancreatic xenograft tumors, with complete tumor regression in 90% of the cases after two injections of the α-amanitin-anti-EpCAM ADC at a dose of 100 μg/kg with respect to α-amanitin.