TLR2 and tuberculosis: EV-TB contained ligands for TLR2/6, which is not unexpected, since several components of Mtb are known TLR2/6 ligands, including lipoarabinomannan (ManLAM), lipomannan, phosphatidylinositol mannoside, and the 19 and 38 kDa lipoproteins (35, 36).