KLRC2 and infection: In TB, NK cells populate the granuloma and can help control the infection via different mechanisms: (1) directly via cytotoxic activity (e.g., release of perforin and granulysin) (37–39), (2) indirectly via signaling to the adaptive system (3, 4, 40–42) and possibly via “innate memory” features (17) such as the specific expansion of the NKG2C+ subset as discussed above in other disease models.