Three other independent studies used panimmunoglobulin IA in patients with severe AD and high total serum IgE applying (i) 1–5 cycles of 5 consecutive aphereses at monthly intervals (6), (ii) 1 cycle of 2–4 consecutive aphereses followed by omalizumab every 2 weeks for 24 weeks (7), and (iii) 3 cycles of 3–4 consecutive aphereses at weeks 1, 3, and 8 (8). This evidence concerns the gene IGHE and Alzheimer disease.