(1, 8, 9)] or infection with various pathogens such as S. pyogenes (35, 94), M. tuberculosis (95), Histoplasma capsulatum (96), infection of mouse macrophages with L. major does not induce HIF-1α accumulation on its own but requires exogenous stimulation by IFN-γ and/or LPS (36). Here, IFNG is linked to infection.