AVP and Hypertension: Multiple abnormalities have been identified in this strain of rats including increased blood brain barrier permeability (Pelisch et al., 2011); upregulated CSF [Na+] (Huang et al., 2004); increased plasma AVP (Serino et al., 2001); increased vascular inflammation (Viel et al., 2010); dysfunctional baroreflex control system (Bugenhagen et al., 2010); and the development of hypertension; following high dietary salt intake (Simchon et al., 1989).