Although CyPJ was relatively uninvestigated previously, a few reports suggested that it might play an important role in tumorigenesis and/or progression in HCC (Chen et al., 2015) and other cancers (Qi et al., 2005; Couch et al., 2016; Gong et al., 2017). The gene discussed is PPIL3; the disease is hepatocellular carcinoma.