Polymorphisms in TLR4 and CD14 have been associated with AD in some studies (Balistreri et al., 2008; Rodríguez-Rodríguez et al., 2008; Chen et al., 2012) and whole genome studies have implicated TLR4 in AD (Li et al., 2015). The gene discussed is TLR4; the disease is Alzheimer disease.