Studies have demonstrated that NFkB pathway regulates the activity of Beta-secretase 1 (BACE1; Buggia-Prevot et al., 2008; Guglielmotto et al., 2012), the crucial enzyme for Aβ production and the BACE1 level in AD brain is increased compared to control (Guglielmotto et al., 2012). Here, NFKB1 is linked to Alzheimer disease.