BACE1 and Alzheimer disease: Studies have demonstrated that NFkB pathway regulates the activity of Beta-secretase 1 (BACE1; Buggia-Prevot et al., 2008; Guglielmotto et al., 2012), the crucial enzyme for Aβ production and the BACE1 level in AD brain is increased compared to control (Guglielmotto et al., 2012).