This review hypothesizes that Gram negative bacterial LPS molecules are present in AD WM and GM where they bind oligodendrocytes and cause an increase in cytokines and oxidative stress that contributes directly to damage of oligodendrocytes and to myelin proteins including MBP which then associate with Aβ1–42 in amyloid plaques in AD brain. The gene discussed is MBP; the disease is Alzheimer disease.