Dysfunction of any of the proteins in this pathway would reduce the normal activation of a key transcription factor, early growth response 3 (EGR3), an immediate early gene that is both associated with schizophrenia in humans (Yamada et al., 2007; Kim et al., 2010; Ning et al., 2012; Zhang et al., 2012; Huentelman et al., 2015), and expressed at reduced levels in patients’ brains (Mexal et al., 2005; Yamada et al., 2007). The gene discussed is EGR3; the disease is schizophrenia.