We have previously highlighted SRF as a protein in the proposed biological pathway for schizophrenia susceptibility based on its requirement for both novelty memory and LTD in mice (Etkin et al., 2006), as well its regulatory interactions with other proteins in the pathway (Etkin et al., 2006; Gallitano-Mendel et al., 2007). Here, SRF is linked to schizophrenia.