EGR3 binds to NAB2 to co-regulate expression of target genes, and is involved in co-regulatory feedback relationships with EGR1, as well EGR1, EGR2 and EGR3 can regulate NAB2 expression, demonstrating a functional interaction of both of these schizophrenia associated genes in the proposed pathway (Svaren et al., 1996; Mechta-Grigoriou et al., 2000; Kumbrink et al., 2005, 2010; Srinivasan et al., 2007). The gene discussed is EGR1; the disease is schizophrenia.