Indeed, numerous genome wide association studies of copy number variations (CNVs), de novo mutations and SNPs (Kirov et al., 2012; Fromer et al., 2014; Purcell et al., 2014), as well as our own resequencing study that identified a schizophrenia associated ARC SNP (Huentelman et al., 2015), have subsequently supported this hypothesis. The gene discussed is ARC; the disease is schizophrenia.