Indeed, VEGF treatment partially rescues motor function of the CMT2D mice and Nrp1 heterozygosity exacerbates it (He et al., 2015), while reduced expression of VEGF in wild-type mice has been shown to contribute to motor neuron degeneration (Oosthuyse et al., 2001). This evidence concerns the gene VEGFA and Charcot-Marie-Tooth disease type 2D.