Inhibitors of Bcl-xL rather than Bcl-2 enhances KPNB1 inhibitor-induced apoptosis in glioblastoma cells, suggesting that combination of Bcl-xL inhibitors and KPNB1 inhibitors, such as IPZ and INI-43 [43], may be efficacious and safe for solid tumors therapy. The gene discussed is BCL2; the disease is glioblastoma.