AKT1 and systemic lupus erythematosus: KEGG pathway annotation29 revealed that the DEPs in AHT and YDSK group both mainly functioned in the signaling pathways of systemic lupus erythematosus (hsa05322), staphylococcus aureus infection (hsa05150), tuberculosis (hsa05152), viral myocarditis (hsa05416), PI3K-Akt signaling pathway (hsa04151) and phospholipase D signaling pathway (hsa04072) (Fig. 3).