TP53 and neoplasm: Gene Ontology annotation indicated that the tumor proteome was significantly enriched in epithelial mesenchymal transition (EMT), cell cycle, DNA replication, checkpoint, E2F, p53 signaling, and inflammatory response pathways, whereas the nearby tissue proteome was enriched in metabolism pathways, such as fatty acid metabolism, oxidative phosphorylation, and amino acid metabolism (Fig. 2a).