HDAC6 and neurodegenerative disease: The removal of the modification is catalyzed by histone deacetylase 6 (HDAC6)29, 30, whose inhibition has been shown to increase α-tubulin acetylation31, rescue axonal transport defects32, and provide benefits in animal models of neurodegenerative diseases, including a subtype of CMT2 (CMT2F)23.