MUC1 and autosomal dominant medullary cystic kidney disease with or without hyperuricemia: As the pathomechanisms in ADTKD-MUC1 are likely linked to inflammatory and immune processes in the kidney tissue and structural variation in the VNTR domain has been shown to alter B lymphocyte response, it is not beyond reason to assume a potential role of the VNTR’s topology here (please see Fig. 5 for further information)30–32.