In PCOS OUH, age, obesity (BMI, waist), BP (systolic and diastolic), lipid status (LDL, cholesterol, TG), prolactin, blood glucose (fasting, 2 h), insulin (fasting, HOMA-ir) were significant predictors for development of CVD (Table 5). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.