In the last years mutational analysis have discovered recurrent mutations and deletions in members of the JAK/STAT signalling pathway (JAK3, STAT3 and STAT5B), in the gene encoding the RNA helicase DDX3X, in tumour suppressor genes including TP53, MGA, PRDM1, FOXO3, HACE1 and in the transcription corepressor BCOR, among others [238,239,240,241] P53 protein overexpression occurs in 45–85% of the cases; however, TP53 mutations are found in 24–62% of the cases and seem to correlate with large-cell morphology and advanced state at diagnosis [219,242]. This evidence concerns the gene PRDM1 and neoplasm.