PRNP and Parkinson disease: Another potential advantage of targeting PrPC arises from recent observations indicating that PrPC may exert a toxicity-transducing activity upon binding to PrPSc, as well as to various disease-associated, misfolded oligomeric assemblies, such as those formed by the amyloid β (Aβ) peptide, or by the protein alpha-synuclein, linked to Alzheimer’s and Parkinson’s diseases, respectively [25,26,27,28,29].