The extracts and juice of pomegranate significantly inhibited the hyperoxaluria-induced oxidative renal tubular damages (due to its antioxidants and anti-lipid-peroxidation [68]) by reducing the levels of reactive oxygen species (ROS), inducible nitric oxide synthase (iNOS), and nuclear factor-κB (NF-κB) [61,69] and p38-mitogen-activated protein kinase (p38-MAPK) [69], and regulating urea, creatinine, and ureic acid [12]. This evidence concerns the gene NOS2 and Hyperoxaluria.