TF and neoplasm: Interestingly, a study aimed at defining the role of coagulation proteins in tumor progression by immunohistochemistry highly localized fibrin II and fragment D of FGB in the stroma at tumor periphery near the host-tumor interface, and co-localized hemostatic proteins with the “vascular endothelial growth factor” (VEGF), activated by the “tissue factor” (TF) produced by tumor cells [38].