Capello 2017 [21]: Began with 17 protein biomarker candidates from previous studies and validated several that can distinguish PDAC from controls and chronic pancreatitis (TIMP1, LRG1, REG3A, IGFBP2, COL18A1, TNFRSF1A), finding TIMP1 + LRG1 + CA19-9 outperformed CA19-9 alone. Evaluation in an independent test set is desirable. This evidence concerns the gene REG3A and chronic pancreatitis.