Mice that lack NLRP3 (Nalp3, Cryopyrin, CIAS1, and PYPAF1) were more susceptible to Candida infections, since the NLRP3 inflammasome aids in epithelial integrity, contributing to irritable bowel disease (IBD) in C. albicans yeast and hyphae morphologies, and leading to excess inflammation [162]. Here, NLRP3 is linked to candidiasis.