CSF2 and neoplasm: While type I NKT cells promote tumor immunosurveillance by direct cytotoxicity towards tumor and other cells or the release of immunostimulatory cytokines such as interferon-γ (IFN-γ) or granulocyte-macrophage colony-stimulating factor (GM-CSF), type II NKT cells actively hinder anti-tumor immunity by promoting the accumulation of suppressive myeloid cells [15,16].