This would appear to contradict the findings that insulin resistance is associated with vasoconstriction and elevated blood pressure, but possibly the contradiction lies in the duration of elevated insulin concentrations and the baseline insulin sensitivity; short-term hyperinsulinaemia in insulin-sensitive individuals induces vasodilatation, while persistent hyperinsulinaemia can lead to insulin resistance, which impairs the vasodilatory response and induces a rise in blood pressure and reduced blood flow through the various mechanisms discussed above. This evidence concerns the gene INS and Insulin resistance.