INS and obesity due to melanocortin 4 receptor deficiency: Again, in multivariate regression analysis, weight loss appears not to be correlated with endothelium-dependent FMD improvement and there is also no correlation with changes in BP, body fat, insulin, insulin resistance or lipids [20,33,40,69], despite many studies showing that obesity is associated with decreased vasodilatation and endothelial dysfunction [20].