NOS3 and Insulin resistance: Biochemistry studies have shown that in endothelial cells, hyperinsulinaemia and insulin resistance are associated with impairment of the inositol 3-kinase-dependent signalling pathway, which leads to the synthesis of nitric oxide, confirming that insulin resistance is associated with vascular dysfunction [69,72,78,79,80], while the increase in plasma asymmetric dimethylarginine (ADMA), an inhibitor of eNOS, correlates with elevated BP and insulin resistance [81,82].