However, higher HS values of KRAS, HER2, and PIK3CA were observed in metastatic tumors than in unpaired primary tumors, and heterogeneity between primary and metastatic tumors in copy‐number alterations may partly contribute to the differences (Ferronika et al., 2017; Sveen et al., 2016). Here, PIK3CA is linked to metastatic neoplasm.