However, higher HS values of KRAS, HER2, and PIK3CA were observed in metastatic tumors than in unpaired primary tumors, and heterogeneity between primary and metastatic tumors in copy‐number alterations may partly contribute to the differences (Ferronika et al., 2017; Sveen et al., 2016). The gene discussed is KRAS; the disease is metastatic neoplasm.