APOE and Alzheimer disease: However, in the AD group those carrying multiple iron SNPs showed a lower median value than their counterpart negative for the iron SNPs (MMSE: 18.7; 15.3–22.5 versus 20.2; 17.6–22.9; P = 0.098) and this variation was more evident within the APOE4(+) subgroups of AD (MMSE: 17.4; 15.4–19.9 versus 19.0; 17.6–22.9; P = 0.038).