APOE and Alzheimer disease: As an example, the crude OR scored for the APOE4 allele in AD patients (OR(APOE4): 4.49; 3.32–6.08) was unmodified by the co-presence of the TF 570S allele (OR(APOE4+TF570S): 3.75; 2.40–5.85), while it completely extinguished when HFE 282Y allele was coinherited (OR(APOE4+HFE282Y): 0.98; 0.21–4.6).