Indeed, both leptin-deficient ob/ob and leptin receptor-deficient db/db mice show a decrease in Dec1 expression in the liver and a significant increase in hepatic triglycerides [61], whereas only a mild increase in hepatic triglyceride content was observed in mice with alcohol-induced fatty liver, in which Dec1 expression was increased [62]. The gene discussed is BHLHE40; the disease is digestive system neoplasm.