AKT1 and neoplasm: Herein, we report the cytotoxic effects and action mechanisms toward A549 cells by a novel marine bacterial polysaccharide EPS11, including: (1) suppressing the adhesion; (2) destroying filiform structures; (3) inducing anoikis through downregulating the expression of βIII-tubulin and AKT phosphorylation; and (4) attenuating tumor incidence and growth in vivo.