The current findings not only are consistent with those in bladder specimens, indicating the prognostic values of p-ELK1 expression in patients with muscle-invasive tumor [11], but also support our observations in preclinical models suggesting that ELK1 promotes the proliferation, migration, and invasion of bladder cancer cells and activates MMP-2 and MMP-9 [10,11]. This evidence concerns the gene MMP2 and urinary bladder carcinoma.