TP53 and neoplasm: For example, the p53 transactivation domain mutant p53L25Q;W26S lacks the ability to induce cell cycle arrest and apoptosis triggered by DNA damage, but retains the ability to induce oncogene-induced senescence; knock-in mice expressing p53L25Q;W26S display significant tumor suppression against oncogenic rat sarcoma viral oncogene homolog (RAS)-induced tumor formation [1].