In particular, CTNNB1, GNAQ, GSK3B, GSTP1, MAPK3, PPP1CC, PRKACA, SMAD4, and PTPN11 were de-regulated (corrected p-values < 0.05) central genes in the tissue samples in our model (Table 1 and Figure 4), representing not only a putative group of biomarkers but also potential therapeutic targets in melanoma metastasis. Here, SMAD4 is linked to melanoma.