In particular, CTNNB1, GNAQ, GSK3B, GSTP1, MAPK3, PPP1CC, PRKACA, and SMAD4 genes (corrected p-value < 0.05; FDR) were over- or sub-expressed in at least two datasets of melanoma metastases when compared with primary tumor samples. The gene discussed is SMAD4; the disease is melanoma.