Pathway analyses identified receptor-mediated signaling (e.g., Wingless, integrin, insulin, PI3K/AKT, IL-4, and hypoxia signaling, many of these involving GSK3β, a therapeutic target of lithium), RNA metabolism, and protein trafficking (e.g., post Golgi vesicle mediated transport and Golgi to plasma membrane transport) as major processes altered in BD-derived late neurons. This evidence concerns the gene GSK3B and Behcet disease.