In the present study, we used the mouse model of myelin oligodendrocyte glycoprotein (MOG) immunization that results in EAE with a high incidence of optic neuritis (see [22]) in order to determine whether nFAG may counteract neuroinflammation with the final aim to address a possible role of this diet supplement in counteracting RGC degeneration. This evidence concerns the gene MOG and optic neuritis.