In particular, CAIX associates with a compendium of integrin subunits, specifically integrin β1 (ITGB1), integrin α2 (ITGA2), integrin α3 (ITGA3), integrin α5 (ITGA5) and integrin α6 (ITGA6) [22], highlighting a potential role of CAIX in coordinating the regulation of collagen- and laminin-binding integrins to control cancer cell adhesion, a critical process involved in migration and invasion (Figure 1). The gene discussed is CA9; the disease is cancer.