Congruent with the findings that MMP14 is a component of the CAIX interactome in cancer cells and that CAIX localizes with MMP14 in pseudopodia-like protrusions, immunoflurescence analyses have now shown that, in breast cancer cells, CAIX specifically co-localizes with MMP14 at functional invadopodia, where it functions to regulate collagen degradation [22]. The gene discussed is CA9; the disease is breast carcinoma.