GNRH1 and central precocious puberty: CPP is associated with premature activation of the hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator.[2] It can lead to a compromised final adult height because of accelerated bone maturation.[3] Therefore timely treatment with GnRH agonist to suppress the hypothalamic–pituitary–ovarian axis is important.[4] IPPs on the other hand are not associated with early epiphyseal closure and do not require therapy, but may mimic the early symptoms of CPPs and cause diagnostic difficulties.[5]