CDKN1A (fold change (fc = −4.94), inhibitor of growth family member 4 and 5 (ING4) (fc = 2.94) and (ING5) (fc = 2.13), tumour protein and TP53 inducible protein 3 (TP53I3) (fc = 2.92), centromere protein O (CENPO) (fc = −2.21) and proteasome activator complex subunit 3 (PSME3) (fc = −2.26)19, 20, 21, 22 were significantly altered in CLL compared to healthy donor samples (Figure 3A and Supporting Information). This evidence concerns the gene CENPO and B-cell chronic lymphocytic leukemia.