Indeed, CDK4 (Figure 3B), ING4 (Figure 3C), ING5 (Figure 3D), TP53I3 (Figure 3E) and CDKN1A (Figure 3F) mRNA expression levels were significantly altered in our cohort of CLL compared to healthy donor samples. The gene discussed is CDK4; the disease is B-cell chronic lymphocytic leukemia.