CDK4 and B-cell chronic lymphocytic leukemia: Moreover, expression levels of cyclin‐dependent kinase 4 (CDK4) (fc = 2.08), cell cycle division cycle protein 16 homolog (CDC16) (fc = 3.81) and cyclin‐dependent kinase 2‐associated protein (CDK2AP) (fc = 2.69), which are involved in centrosome duplication,23, 24, 25 were increased in CLL compared to healthy samples (Figure 3A and Supporting Information).