People carrying three “harmful alleles” had a higher risk of CRC than those who carrying less “harmful alleles.” Interestingly, there were 11 CRC cases (9.91%) carrying three “harmful alleles” and two patients (1.80%) carrying four “harmful alleles,” but in control group, there was no people carrying three or four “harmful alleles.” It seems to have a synergism of MLH3 rs108621 C and ERCC1 rs3212986 A alleles to predict the risk of CRC, which may provide a new and interesting data and contribute to predict the risk of CRC. Here, MLH3 is linked to colorectal carcinoma.