Nevertheless, some recent reports have indicated that INPP4B acts as an oncogenic driver by activating SGK3 in several kinds of cancer cells.13, 15, 24 As a member of a serine/threonine protein kinase family, SGK3 is highly homologous to and shares substrate specificity to the protein kinase B (PKB)/AKT family.25 Tessier et al25 reported that the main product of INPP4B, PI(3)P, can bind to a Phox homology domain of SGK3, thereby targeting the protein to endosomes, where PI3K and PDK1 phosphorylate SGK3 at two regulatory sites (Thr‐320 and Ser‐486). This evidence concerns the gene AKT1 and cancer.