Yang et al demonstrate that NF‐κB up‐regulates the expression of miR‐21, by binding to its gene promoter.49 Other studies also document NF‐κB binding sites on the promoter of miR‐21.34, 50 Furthermore, STAT3, a crucial gene in progression of HNSCC,40, 41 has also been previously implicated in up‐regulation of miR‐21, in a manner of NF‐κB‐dependent IL‐6 up‐regulation.34 The NF‐κB/IL‐6/STAT3/miR‐21 interaction therefore appears to be supported by the effect of BAY 11‐7082 in down‐regulating the expression of these oncogenic factors. This evidence concerns the gene IL6 and head and neck squamous cell carcinoma.