Alternatively, it has been shown that STAT3 can directly repress miR‐34a, while an active IL‐6R/STAT3/miR‐34a loop was found necessary for EMT, invasion and metastasis of colorectal cancer cell line.56 Our current data support the notion that NF‐κB inhibition is capable of preventing down‐regulation of miR‐34a by acidic bile. This evidence concerns the gene STAT3 and colorectal cancer.