NFKB1 and cancer: Whereas the ratio of miR‐21/375 has been considered a potential biomarker related to poor prognosis of supraglottic cancer,13, 14 our data demonstrate a significant increase in miR‐21/375 ratios in cells exposed to acidic bile (pH 4.0), compared to controls, a relationship that is effectively inverted in the presence of NF‐κB inhibitor, again strongly supporting the miR‐21/375 ratio, as a potential biomarker in acidic bile‐induced cancer‐related molecular events in hypopharyngeal cells, mediated by NF‐κB pathway.