We present strong interactions among the BAY 11‐7082‐induced expression levels of the analysed cancer‐related miRNA markers and well‐known mediators of inflammatory and oncogenic pathways, including RELA(p65), TNF‐α and IL‐6 or IL‐1β and oncogenic STAT3, suggesting a protective role of NF‐κB inhibition in acidic bile‐induced inflammatory events linked to cancer. This evidence concerns the gene TNF and cancer.