Previous studies reveal that UHRF1 is overexpressed in almost all histological types of lung cancer and correlates with a poor prognosis, which can be useful for diagnosis of lung cancer in all pathological stages.25 In NSCLC, UHRF1 overexpression resulted in the silencing of tumour suppressor genes by maintaining their promoters in a hypermethylated state.26 This evidence concerns the gene UHRF1 and lung cancer.