Of the genes that were significantly differentially expressed in all CRC tumors combined, all but TUBA3E, were not downregulated in MSS tumors with a FC of < 0.67, and several genes (NTRK1, FAS, CASP10, TUBA8, CTSS, FASLG, BLS2L11, LMNA, MAP3K14, BIRC3, and EIF2AK3) were not downregulated in MSI tumors with a FC of < 0.67, although power was more limited when examined MSI-specific associations. The gene discussed is MAP3K14; the disease is Marinesco-Sjogren syndrome.