AKAP9 and Alzheimer disease: In the same study, there was strong evidence for association of rs149454736 (MAF = 0.03), which is located between exons 45 and 46 of AKAP9 and is only 1513 bp from rs149979865, with a brain MRI measure of hippocampal volume in AD subjects (p = 2.2 × 10−7).