Recently, a genome-wide association study of AD-related endophenotypes in the ADNI study cohort subjects of European ancestry with mild cognitive impairment revealed significant association of several common SNPs (minor allele frequency, MAF = 0.45 and located 381 kb upstream of AKAP9) with pTau level (p < 6.9 × 10−7 for all SNPs) (Chung et al. 2018). This evidence concerns the gene AKAP9 and Cognitive impairment.