Tumor-derived exomes bearing NKG2D ligands (such as MIC-A/B and ULBP 1 and 2) were also shown to act as decoys, impairing NKG2D-mediated NK-cell cytotoxicity and facilitating the immune evasion of leukemia/lymphoma cells (Hedlund et al., 2011). This evidence concerns the gene KLRK1 and leukemia.