In a recent report, De Veirman et al. showed that myeloma-derived exosomes can transfer miR-146a to mesenchymal cells, leading to the secretion of several cytokines and chemokines by these recipient cells, including CXCL1, IL6, IL-8, IP-10, MCP-1, and CCL-5, and to the promotion of myeloma cells migration and survival (De Veirman et al., 2016). Here, CXCL1 is linked to plasma cell myeloma.