In chronic lymphocytic leukemia (CLL), tumor-derived exosomes containing noncoding Y RNA hY4 were shown to induce CLL-associated phenotypes in recipient monocytes, including the release of cytokines, such as C-C motif chemokine ligand 2 (CCL2), CCL4, and IL-6, and the expression of PD-L1, suggesting a potential exosome-based mechanism of immune escape (Haderk et al., 2017). This evidence concerns the gene CCL4 and B-cell chronic lymphocytic leukemia.