It was also demonstrated that upregulation of Heparanase in tumor cells, including myeloma and breast cancers, is associated with increased exosomes production and exosomal packaging of Syndecan-1, Vascular Endothelial Growth Factor (VEGF) and Hepatocyte Growth Factor, which lead to increased endothelial invasion through the ECM (Thompson et al., 2013). This evidence concerns the gene VEGFA and breast carcinoma.