For example, once taken up by hepatic resident macrophages, in a mechanism mediated by exosomal Integrin αVβ5 (Hoshino et al., 2015), pancreatic cancer-derived exosomes containing high levels of Macrophage Migration Inhibitory Factor (MIF) (Costa-Silva et al., 2015) were shown to induce upregulation of secreted factors associated with liver fibrosis, such as TGFβ (Costa-Silva et al., 2015), and pro-inflammatory genes involved with metastasis, such as S100A8 and S100P (Lukanidin and Sleeman, 2012; Hoshino et al., 2015). This evidence concerns the gene MIF and familial pancreatic carcinoma.