Recently, a study found that the combination of anti-VEGFR2 and anti-PD-L1 antibodies induced the generation of endothelial venules(HEVs), which promoted lymphocyte infiltration through the activation of lymphotoxin β receptor (LTβR) signaling in breast cancer and pancreatic neuroendocrine cancers. Here, LTBR is linked to pancreatic endocrine carcinoma.