A number of pathways differentially regulated by GPx4 in human HCC deals with immune cell and their transmigration and include diapedesis of granulocytes (neutrophils, basophils and eosinophils) and agranulocytes ( lymphocytes and monocytes) as well as B cell development and primary immunodeficiency signaling (Table 1). The gene discussed is GPX4; the disease is hepatocellular carcinoma.