Only 2 variants (the missense variant BUB1B c.2161C > A / p.Pro721Thr and the synonymous variant EP300 c.2871T > A / p.T957T) occurred in the primary angiosarcoma that did not occur in the local recurrence; however, 14 variants in 11 genes were present in both the primary and recurrent lesions (including 2 missense variants and 1 splice site loss, Table 3). Here, EP300 is linked to angiosarcoma.